Combined Effects of Pericytes in the Tumor Microenvironment

Combined Effects of Pericytes in the Tumor Microenvironment

Pericytes are multipotent perivascular cells whose involvement in vasculature development is well established. Evidences in the literature also suggest that pericytes display immune properties and that these cells may serve as an in vivo reservoir of stem cells, contributing to the regeneration of d...

Full description

Bibliographic Details
Main Authors: Aline Lopes Ribeiro, Oswaldo Keith Okamoto
Format: Article
Language:English
Published: Hindawi Limited 2015-01-01
Series:Stem Cells International
Online Access:http://dx.doi.org/10.1155/2015/868475
id doaj-1449c495cd5e49e3a4f50142732f4c88
record_format Article
spelling doaj-1449c495cd5e49e3a4f50142732f4c882020-11-24T22:02:18ZengHindawi LimitedStem Cells International1687-966X1687-96782015-01-01201510.1155/2015/868475868475Combined Effects of Pericytes in the Tumor MicroenvironmentAline Lopes Ribeiro0Oswaldo Keith Okamoto1Centro de Pesquisa sobre o Genoma Humano e Células-Tronco, Departamento de Genética e Biologia Evolutiva, Instituto de Biociências, Universidade de São Paulo, Rua do Matão 277, Cidade Universitária, 05508-090 São Paulo, SP, BrazilCentro de Pesquisa sobre o Genoma Humano e Células-Tronco, Departamento de Genética e Biologia Evolutiva, Instituto de Biociências, Universidade de São Paulo, Rua do Matão 277, Cidade Universitária, 05508-090 São Paulo, SP, BrazilPericytes are multipotent perivascular cells whose involvement in vasculature development is well established. Evidences in the literature also suggest that pericytes display immune properties and that these cells may serve as an in vivo reservoir of stem cells, contributing to the regeneration of diverse tissues. Pericytes are also capable of tumor homing and are important cellular components of the tumor microenvironment (TME). In this review, we highlight the contribution of pericytes to some classical hallmarks of cancer, namely, tumor angiogenesis, growth, metastasis, and evasion of immune destruction, and discuss how collectively these hallmarks could be tackled by therapies targeting pericytes, providing a rationale for cancer drugs aiming at the TME.http://dx.doi.org/10.1155/2015/868475
collection DOAJ
language English
format Article
sources DOAJ
author Aline Lopes Ribeiro
Oswaldo Keith Okamoto
spellingShingle Aline Lopes Ribeiro
Oswaldo Keith Okamoto
Combined Effects of Pericytes in the Tumor Microenvironment
Stem Cells International
author_facet Aline Lopes Ribeiro
Oswaldo Keith Okamoto
author_sort Aline Lopes Ribeiro
title Combined Effects of Pericytes in the Tumor Microenvironment
title_short Combined Effects of Pericytes in the Tumor Microenvironment
title_full Combined Effects of Pericytes in the Tumor Microenvironment
title_fullStr Combined Effects of Pericytes in the Tumor Microenvironment
title_full_unstemmed Combined Effects of Pericytes in the Tumor Microenvironment
title_sort combined effects of pericytes in the tumor microenvironment
publisher Hindawi Limited
series Stem Cells International
issn 1687-966X
1687-9678
publishDate 2015-01-01
description Pericytes are multipotent perivascular cells whose involvement in vasculature development is well established. Evidences in the literature also suggest that pericytes display immune properties and that these cells may serve as an in vivo reservoir of stem cells, contributing to the regeneration of diverse tissues. Pericytes are also capable of tumor homing and are important cellular components of the tumor microenvironment (TME). In this review, we highlight the contribution of pericytes to some classical hallmarks of cancer, namely, tumor angiogenesis, growth, metastasis, and evasion of immune destruction, and discuss how collectively these hallmarks could be tackled by therapies targeting pericytes, providing a rationale for cancer drugs aiming at the TME.
url http://dx.doi.org/10.1155/2015/868475
work_keys_str_mv AT alinelopesribeiro combinedeffectsofpericytesinthetumormicroenvironment
AT oswaldokeithokamoto combinedeffectsofpericytesinthetumormicroenvironment
_version_ 1725836623034187776

Similar Items