FGF21 Protects against Aggravated Blood-Brain Barrier Disruption after Ischemic Focal Stroke in Diabetic db/db Male Mice via Cerebrovascular PPARγ Activation

FGF21 Protects against Aggravated Blood-Brain Barrier Disruption after Ischemic Focal Stroke in Diabetic db/db Male Mice via Cerebrovascular PPARγ Activation

Recombinant fibroblast growth factor 21 (rFGF21) has been shown to be potently beneficial for improving long-term neurological outcomes in type 2 diabetes mellitus (T2DM) stroke mice. Here, we tested the hypothesis that rFGF21 protects against poststroke blood−brain barrier (BBB) damage in...

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Bibliographic Details
Main Authors:	Yinghua Jiang, Li Lin, Ning Liu, Qingzhi Wang, Jing Yuan, Yadan Li, Kelly K. Chung, Shuzhen Guo, Zhanyang Yu, Xiaoying Wang
Format:	Article
Language:	English
Published:	MDPI AG 2020-01-01
Series:	International Journal of Molecular Sciences
Subjects:	focal ischemic stroke type 2 diabetes db/db mouse fibroblast growth factor 21 blood—brain barrier human brain microvascular endothelial cell
Online Access:	https://www.mdpi.com/1422-0067/21/3/824

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