Administration of a selective retinoic acid receptor-γ agonist improves neuromuscular strength in a rodent model of volumetric muscle loss

Administration of a selective retinoic acid receptor-γ agonist improves neuromuscular strength in a rodent model of volumetric muscle loss

Abstract Purpose Volumetric muscle loss is a uniquely challenging pathology that results in irrecoverable functional deficits. Furthermore, a breakthrough drug or bioactive factor has yet to be established that adequately improves repair of these severe skeletal muscle injuries. This study sought to...

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Bibliographic Details
Main Authors: Michael E. Whitely, Patrick B. Collins, Masahiro Iwamoto, Joseph C. Wenke
Format: Article
Language:English
Published: SpringerOpen 2021-08-01
Series:Journal of Experimental Orthopaedics
Subjects:
Volumetric muscle loss
Muscle function
Palovarotene
RAR agonist
Online Access:https://doi.org/10.1186/s40634-021-00378-3

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