Computed tomography calcium scoring association and reclassification of clinical cardiovascular risk in asymptomatic Mexican patients

Objectives: To establish tailored preventive treatment, we studied the ability of coronary artery calcium scoring to reclassify patients with intermediate cardiovascular risk and its association with additional risk factors in our Mexican preventive care center. Materials and methods: In this retros...

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Main Authors: Aldo Javier Vázquez Mézquita, Michelle Claire Williams, Rafael Choza Chenhalls, Nancy Berenice Guzmán Martínez, Ana Patricia Chischistz Condey, Maria José Acosta Falomir, Marco Antonio Téliz Meneses, María Nayeli Vázquez Sánchez
Format: Article
Language:English
Published: SAGE Publishing 2020-07-01
Series:SAGE Open Medicine
Online Access:https://doi.org/10.1177/2050312120938233
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spelling doaj-1423330b1c654265ad5e55ccb88738472020-11-25T02:42:14ZengSAGE PublishingSAGE Open Medicine2050-31212020-07-01810.1177/2050312120938233Computed tomography calcium scoring association and reclassification of clinical cardiovascular risk in asymptomatic Mexican patientsAldo Javier Vázquez Mézquita0Michelle Claire Williams1Rafael Choza Chenhalls2Nancy Berenice Guzmán Martínez3Ana Patricia Chischistz Condey4Maria José Acosta Falomir5Marco Antonio Téliz Meneses6María Nayeli Vázquez Sánchez7Department of Radiology and Molecular Imaging, Centro Médico ABC (The American British Cowdray Medical Center), Mexico City, MexicoUniversity/BHF Centre for Cardiovascular Science, The University of Edinburgh, Edinburgh, UKDepartment of Radiology, Biomédica de Referencia, Mexico City, MexicoDepartment of Radiology and Molecular Imaging, Centro Médico ABC (The American British Cowdray Medical Center), Mexico City, MexicoDepartment of Radiology and Molecular Imaging, Centro Médico ABC (The American British Cowdray Medical Center), Mexico City, MexicoDepartment of Radiology and Molecular Imaging, Centro Médico ABC (The American British Cowdray Medical Center), Mexico City, MexicoDepartment of Radiology and Molecular Imaging, Centro Médico ABC (The American British Cowdray Medical Center), Mexico City, MexicoDepartment of Radiology and Molecular Imaging, Centro Médico ABC (The American British Cowdray Medical Center), Mexico City, MexicoObjectives: To establish tailored preventive treatment, we studied the ability of coronary artery calcium scoring to reclassify patients with intermediate cardiovascular risk and its association with additional risk factors in our Mexican preventive care center. Materials and methods: In this retrospective cohort study, we analyzed 520 asymptomatic patients from a Mexican primary prevention population between 2014 and 2018. Coronary artery calcium scoring, laboratory results, and anthropometric measurements (abdominal circumference and body mass index) were assessed. The Framingham risk score and American Heart Association/American College of Cardiology (AHA/ACC) atherosclerotic cardiovascular disease risk algorithm were calculated. Correlations between coronary artery calcium scoring, anthropometric measurements, and clinical cardiovascular risk scores were assessed. We assessed the ability of coronary artery calcium scoring to reclassify patients recommended for statin therapy compared with the cardiovascular risk scores. Results: Patients had a mean age of 67.5 years ( SD  ± 9.8) and 294 subjects (56.5%) were male. Coronary artery calcium scoring has a positive correlation with age, AHA/ACC atherosclerotic cardiovascular disease risk algorithm, and Framingham risk score ( p  < 0.001 for all). Coronary artery calcium scoring was prevalent, occurring in 63.2% of patients with a median Agatston score of 22 with and interquartile range of 178. Male gender, older age, smoking habit, diabetes, and abdominal circumference were independent predictors of coronary artery calcium scoring ( p  < 0.001). Coronary artery calcium scoring downwardly reclassified 44.9% of patients in intermediate cardiovascular risk categories by the AHA/ACC atherosclerotic cardiovascular disease risk algorithm and 43.9% by the Framingham risk score. Coronary artery calcium scoring upwardly reclassified 46.8% of patients in intermediate risk categories by the AHA/ACC atherosclerotic cardiovascular disease risk algorithm and 56% by the Framingham risk score. Conclusion: Coronary artery calcium scoring is prevalent in this Mexican primary prevention cohort and has the ability to reclassify a significant percentage of intermediate cardiovascular risk patients.https://doi.org/10.1177/2050312120938233
collection DOAJ
language English
format Article
sources DOAJ
author Aldo Javier Vázquez Mézquita
Michelle Claire Williams
Rafael Choza Chenhalls
Nancy Berenice Guzmán Martínez
Ana Patricia Chischistz Condey
Maria José Acosta Falomir
Marco Antonio Téliz Meneses
María Nayeli Vázquez Sánchez
spellingShingle Aldo Javier Vázquez Mézquita
Michelle Claire Williams
Rafael Choza Chenhalls
Nancy Berenice Guzmán Martínez
Ana Patricia Chischistz Condey
Maria José Acosta Falomir
Marco Antonio Téliz Meneses
María Nayeli Vázquez Sánchez
Computed tomography calcium scoring association and reclassification of clinical cardiovascular risk in asymptomatic Mexican patients
SAGE Open Medicine
author_facet Aldo Javier Vázquez Mézquita
Michelle Claire Williams
Rafael Choza Chenhalls
Nancy Berenice Guzmán Martínez
Ana Patricia Chischistz Condey
Maria José Acosta Falomir
Marco Antonio Téliz Meneses
María Nayeli Vázquez Sánchez
author_sort Aldo Javier Vázquez Mézquita
title Computed tomography calcium scoring association and reclassification of clinical cardiovascular risk in asymptomatic Mexican patients
title_short Computed tomography calcium scoring association and reclassification of clinical cardiovascular risk in asymptomatic Mexican patients
title_full Computed tomography calcium scoring association and reclassification of clinical cardiovascular risk in asymptomatic Mexican patients
title_fullStr Computed tomography calcium scoring association and reclassification of clinical cardiovascular risk in asymptomatic Mexican patients
title_full_unstemmed Computed tomography calcium scoring association and reclassification of clinical cardiovascular risk in asymptomatic Mexican patients
title_sort computed tomography calcium scoring association and reclassification of clinical cardiovascular risk in asymptomatic mexican patients
publisher SAGE Publishing
series SAGE Open Medicine
issn 2050-3121
publishDate 2020-07-01
description Objectives: To establish tailored preventive treatment, we studied the ability of coronary artery calcium scoring to reclassify patients with intermediate cardiovascular risk and its association with additional risk factors in our Mexican preventive care center. Materials and methods: In this retrospective cohort study, we analyzed 520 asymptomatic patients from a Mexican primary prevention population between 2014 and 2018. Coronary artery calcium scoring, laboratory results, and anthropometric measurements (abdominal circumference and body mass index) were assessed. The Framingham risk score and American Heart Association/American College of Cardiology (AHA/ACC) atherosclerotic cardiovascular disease risk algorithm were calculated. Correlations between coronary artery calcium scoring, anthropometric measurements, and clinical cardiovascular risk scores were assessed. We assessed the ability of coronary artery calcium scoring to reclassify patients recommended for statin therapy compared with the cardiovascular risk scores. Results: Patients had a mean age of 67.5 years ( SD  ± 9.8) and 294 subjects (56.5%) were male. Coronary artery calcium scoring has a positive correlation with age, AHA/ACC atherosclerotic cardiovascular disease risk algorithm, and Framingham risk score ( p  < 0.001 for all). Coronary artery calcium scoring was prevalent, occurring in 63.2% of patients with a median Agatston score of 22 with and interquartile range of 178. Male gender, older age, smoking habit, diabetes, and abdominal circumference were independent predictors of coronary artery calcium scoring ( p  < 0.001). Coronary artery calcium scoring downwardly reclassified 44.9% of patients in intermediate cardiovascular risk categories by the AHA/ACC atherosclerotic cardiovascular disease risk algorithm and 43.9% by the Framingham risk score. Coronary artery calcium scoring upwardly reclassified 46.8% of patients in intermediate risk categories by the AHA/ACC atherosclerotic cardiovascular disease risk algorithm and 56% by the Framingham risk score. Conclusion: Coronary artery calcium scoring is prevalent in this Mexican primary prevention cohort and has the ability to reclassify a significant percentage of intermediate cardiovascular risk patients.
url https://doi.org/10.1177/2050312120938233
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