Live imaging of osteoclast inhibition by bisphosphonates in a medaka osteoporosis model

Osteoclasts are bone-resorbing cells derived from the monocyte/macrophage lineage. Excess osteoclast activity leads to reduced bone mineral density, a hallmark of diseases such as osteoporosis. Processes that regulate osteoclast activity are therefore targeted in current osteoporosis therapies. To i...

Full description

Bibliographic Details
Main Authors: Tingsheng Yu, Paul Eckhard Witten, Ann Huysseune, Anita Buettner, Thuy Thanh To, Christoph Winkler
Format: Article
Language:English
Published: The Company of Biologists 2016-02-01
Series:Disease Models & Mechanisms
Subjects:
Online Access:http://dmm.biologists.org/content/9/2/155