Hepatoprotective Effect of Silymarin (Silybum marianum) on Hepatotoxicity Induced by Acetaminophen in Spontaneously Hypertensive Rats

Hepatoprotective Effect of Silymarin (Silybum marianum) on Hepatotoxicity Induced by Acetaminophen in Spontaneously Hypertensive Rats

This study was aimed to investigate the effect of Silymarin (SLM) on the hypertension state and the liver function changes induced by acetaminophen (APAP) in spontaneously hypertensive rat (SHR). Animals normotensive (N) or hypertensive (SHR) were treated or not with APAP (3 g/kg, oral) or previousl...

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Main Authors: Abel Felipe Freitag, Gabriel Fernando Esteves Cardia, Bruno Ambrósio da Rocha, Rafael Pazzinatto Aguiar, Francielli Maria de Souza Silva-Comar, Ricardo Alexandre Spironello, Renata Grespan, Silvana Martins Caparroz-Assef, Ciomar Aparecida Bersani-Amado, Roberto Kenji Nakamura Cuman
Format: Article
Language:English
Published: Hindawi Limited 2015-01-01
Series:Evidence-Based Complementary and Alternative Medicine
Online Access:http://dx.doi.org/10.1155/2015/538317

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