Human Herpesvirus Sequencing in the Genomic Era: The Growing Ranks of the Herpetic Legion

Human Herpesvirus Sequencing in the Genomic Era: The Growing Ranks of the Herpetic Legion

The nine human herpesviruses are some of the most ubiquitous pathogens worldwide, causing life-long latent infection in a variety of different tissues. Human herpesviruses range from mild childhood infections to known tumour viruses and ‘trolls of transplantation’. Epstein-Barr v...

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Main Author: Charlotte J. Houldcroft
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Pathogens
Subjects:
genomics
herpesviruses
dna viruses
population genetics
clinical sequencing
Online Access:https://www.mdpi.com/2076-0817/8/4/186
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spelling doaj-13f31cd900974ad68183655922e493ee2020-11-25T02:03:41ZengMDPI AGPathogens2076-08172019-10-018418610.3390/pathogens8040186pathogens8040186Human Herpesvirus Sequencing in the Genomic Era: The Growing Ranks of the Herpetic LegionCharlotte J. Houldcroft0Department of Medicine, Addenbrooke’s Hospital, University of Cambridge, Cambs CB2 0QQ UKThe nine human herpesviruses are some of the most ubiquitous pathogens worldwide, causing life-long latent infection in a variety of different tissues. Human herpesviruses range from mild childhood infections to known tumour viruses and ‘trolls of transplantation’. Epstein-Barr virus was the first human herpesvirus to have its whole genome sequenced; GenBank now includes thousands of herpesvirus genomes. This review will cover some of the recent advances in our understanding of herpesvirus diversity and disease that have come about as a result of new sequencing technologies, such as target enrichment and long-read sequencing. It will also look at the problem of resolving mixed-genotype infections, whether with short or long-read sequencing methods; and conclude with some thoughts on the future of the field as herpesvirus population genomics becomes a reality.https://www.mdpi.com/2076-0817/8/4/186genomicsherpesvirusesdna virusespopulation geneticsclinical sequencing
collection DOAJ
language English
format Article
sources DOAJ
author Charlotte J. Houldcroft
spellingShingle Charlotte J. Houldcroft
Human Herpesvirus Sequencing in the Genomic Era: The Growing Ranks of the Herpetic Legion
Pathogens
genomics
herpesviruses
dna viruses
population genetics
clinical sequencing
author_facet Charlotte J. Houldcroft
author_sort Charlotte J. Houldcroft
title Human Herpesvirus Sequencing in the Genomic Era: The Growing Ranks of the Herpetic Legion
title_short Human Herpesvirus Sequencing in the Genomic Era: The Growing Ranks of the Herpetic Legion
title_full Human Herpesvirus Sequencing in the Genomic Era: The Growing Ranks of the Herpetic Legion
title_fullStr Human Herpesvirus Sequencing in the Genomic Era: The Growing Ranks of the Herpetic Legion
title_full_unstemmed Human Herpesvirus Sequencing in the Genomic Era: The Growing Ranks of the Herpetic Legion
title_sort human herpesvirus sequencing in the genomic era: the growing ranks of the herpetic legion
publisher MDPI AG
series Pathogens
issn 2076-0817
publishDate 2019-10-01
description The nine human herpesviruses are some of the most ubiquitous pathogens worldwide, causing life-long latent infection in a variety of different tissues. Human herpesviruses range from mild childhood infections to known tumour viruses and ‘trolls of transplantation’. Epstein-Barr virus was the first human herpesvirus to have its whole genome sequenced; GenBank now includes thousands of herpesvirus genomes. This review will cover some of the recent advances in our understanding of herpesvirus diversity and disease that have come about as a result of new sequencing technologies, such as target enrichment and long-read sequencing. It will also look at the problem of resolving mixed-genotype infections, whether with short or long-read sequencing methods; and conclude with some thoughts on the future of the field as herpesvirus population genomics becomes a reality.
topic genomics
herpesviruses
dna viruses
population genetics
clinical sequencing
url https://www.mdpi.com/2076-0817/8/4/186
work_keys_str_mv AT charlottejhouldcroft humanherpesvirussequencinginthegenomicerathegrowingranksoftheherpeticlegion
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