A Review of Molecular Mechanisms Involved in Toxicity of Nanoparticles

In recent decades, the use of nanomaterials has received much attention in industrial and medical fields. However, some reports have mentioned adverse effects of these materials on the biological systems and cellular components. There are several major mechanisms for cytotoxicity of nanoparticles (N...

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Main Authors:	Javad Khalili Fard, Samira Jafari, Mohammad Ali Eghbal
Format:	Article
Language:	English
Published:	Tabriz University of Medical Sciences 2015-11-01
Series:	Advanced Pharmaceutical Bulletin
Subjects:	Oxidative stress Reactivity oxygen species Cytotoxicity Nanoparticles Mechanism Prooxidant effects
Online Access:	http://journals.tbzmed.ac.ir/APB/Manuscript/APB-5-447.pdf

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record_format	Article
spelling	doaj-13e60f3c45314d8b9aed6ce7f75dae0e2020-11-24T23:06:00ZengTabriz University of Medical Sciences Advanced Pharmaceutical Bulletin2228-58812251-73082015-11-015444745410.15171/apb.2015.061APB_666_20150204160431A Review of Molecular Mechanisms Involved in Toxicity of NanoparticlesJavad Khalili Fard0Samira Jafari1Mohammad Ali Eghbal2Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.Student Research Committee, Tabriz University of Medical Science, Tabriz, Iran. Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.In recent decades, the use of nanomaterials has received much attention in industrial and medical fields. However, some reports have mentioned adverse effects of these materials on the biological systems and cellular components. There are several major mechanisms for cytotoxicity of nanoparticles (NPs) such as physicochemical properties, contamination with toxic element, fibrous structure, high surface charge and radical species generation. In this review, a brief key mechanisms involved in toxic effect of NPs are given, followed by the in vitro toxicity assays of NPs and prooxidant effects of several NPs such as carbon nanotubes, titanium dioxide NPs, quantum dots, gold NPs and silver NPs.http://journals.tbzmed.ac.ir/APB/Manuscript/APB-5-447.pdfOxidative stressReactivity oxygen speciesCytotoxicityNanoparticlesMechanismProoxidant effects
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Javad Khalili Fard Samira Jafari Mohammad Ali Eghbal
spellingShingle	Javad Khalili Fard Samira Jafari Mohammad Ali Eghbal A Review of Molecular Mechanisms Involved in Toxicity of Nanoparticles Advanced Pharmaceutical Bulletin Oxidative stress Reactivity oxygen species Cytotoxicity Nanoparticles Mechanism Prooxidant effects
author_facet	Javad Khalili Fard Samira Jafari Mohammad Ali Eghbal
author_sort	Javad Khalili Fard
title	A Review of Molecular Mechanisms Involved in Toxicity of Nanoparticles
title_short	A Review of Molecular Mechanisms Involved in Toxicity of Nanoparticles
title_full	A Review of Molecular Mechanisms Involved in Toxicity of Nanoparticles
title_fullStr	A Review of Molecular Mechanisms Involved in Toxicity of Nanoparticles
title_full_unstemmed	A Review of Molecular Mechanisms Involved in Toxicity of Nanoparticles
title_sort	review of molecular mechanisms involved in toxicity of nanoparticles
publisher	Tabriz University of Medical Sciences
series	Advanced Pharmaceutical Bulletin
issn	2228-5881 2251-7308
publishDate	2015-11-01
description	In recent decades, the use of nanomaterials has received much attention in industrial and medical fields. However, some reports have mentioned adverse effects of these materials on the biological systems and cellular components. There are several major mechanisms for cytotoxicity of nanoparticles (NPs) such as physicochemical properties, contamination with toxic element, fibrous structure, high surface charge and radical species generation. In this review, a brief key mechanisms involved in toxic effect of NPs are given, followed by the in vitro toxicity assays of NPs and prooxidant effects of several NPs such as carbon nanotubes, titanium dioxide NPs, quantum dots, gold NPs and silver NPs.
topic	Oxidative stress Reactivity oxygen species Cytotoxicity Nanoparticles Mechanism Prooxidant effects
url	http://journals.tbzmed.ac.ir/APB/Manuscript/APB-5-447.pdf
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A Review of Molecular Mechanisms Involved in Toxicity of Nanoparticles

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