A Review of Molecular Mechanisms Involved in Toxicity of Nanoparticles
In recent decades, the use of nanomaterials has received much attention in industrial and medical fields. However, some reports have mentioned adverse effects of these materials on the biological systems and cellular components. There are several major mechanisms for cytotoxicity of nanoparticles (N...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Tabriz University of Medical Sciences
2015-11-01
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| Series: | Advanced Pharmaceutical Bulletin |
| Subjects: | |
| Online Access: | http://journals.tbzmed.ac.ir/APB/Manuscript/APB-5-447.pdf |
| Summary: | In recent decades, the use of nanomaterials has
received much attention in industrial and medical fields. However, some reports
have mentioned adverse effects of these materials on the biological systems and
cellular components. There are several major mechanisms for cytotoxicity of
nanoparticles (NPs) such as physicochemical properties, contamination with
toxic element, fibrous structure, high surface charge and radical species
generation. In this review, a brief key mechanisms involved in toxic effect of NPs
are given, followed by the in vitro toxicity assays of NPs and prooxidant
effects of several NPs such as carbon nanotubes, titanium dioxide NPs, quantum
dots, gold NPs and silver NPs. |
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| ISSN: | 2228-5881 2251-7308 |