Optimal Dose of Intrathecal Dexmedetomidine in Lower Abdominal Surgeries in Average Indian Adult
Background: Dexmedetomidine, a selective alpha2 adrenoceptor agonist, has been used as adjuvant to spinal anaesthesia. Aim: To find out the optimum dose of dexmedetomidine to be used in lower abdomen surgery intrathecally. Materials and Methods: This was a randomized, controlled, double blinded...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2016-04-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/7611/18008_CE[Ra1]_F(P)_PF1(AYAK)_PFA(AK)_PF2(PAG).pdf |
| Summary: | Background: Dexmedetomidine, a selective alpha2 adrenoceptor agonist, has been used as adjuvant to spinal anaesthesia.
Aim: To find out the optimum dose of dexmedetomidine to be
used in lower abdomen surgery intrathecally.
Materials and Methods: This was a randomized, controlled,
double blinded study which included adult ASA I and II patients.
They were allocated into five groups (n=20). Patients allergic
to drugs to be used in the study and those with co-existing
neurological disorders, coagulopathies, cardiac diseases,
obesity and hypertension were excluded. Groups were designed
as 2.5ml hyperbaric bupivacaine with 0.5ml saline (Control) or
0.5ml dexmedetomidine: 5mcg (D1), 10mcg (D2), 15 mcg (D3)
and 20mcg (D4). Data were collected for 10 point VRS for pain,
Bromage motor block, Ramsay sedation score, haemodynamics,
time of first rescue analgesia (TRA) and any adverse effects
and groups were analysed using one way analysis of variance
(ANOVA) by SPSS16.0 (p-value <0.05 significant).
Results: The mean duration of analgesia and need of first
rescue analgesics are 201.5±29.1 mins in control group but in
D1 group 259.1±15.2 mins, D2 310.7±48.1mins, D3 540.3±51.6
mins and D4 702.4±52 mins. p=0.003. The mean highest VRS
score along with analgesic requirements were significantly
reduced in dexemeditomidine groups, but D3 and D4 had
hypotension which needed correction.
Conclusion: Weighing the prolongation of anesthesia and
analgesia and side effects we conclude that 10 mcg of
dexmedetomidine is optimum intrathecal dose. |
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| ISSN: | 2249-782X 0973-709X |