Clinical Assessment of Weight Gain with Atypical Antipsychotics - Blonanserin vs Amisulpride

• Main Authors: TS DEEPAK, BN RAVEESH, BM PARASHIVAMURTHY, MS NARENDRA KUMAR, SUMANTH MALLIKARJUNA MAJGI, HN NAGESH
• Format: Article
• Language: English
• Published: JCDR Research and Publications Private Limited 2015-06-01
• Series: Journal of Clinical and Diagnostic Research
• Subjects: metabolic adverse effects; psychosis; randomized controlled trial
• Online Access: https://jcdr.net/articles/PDF/6066/13007_CE[Ra1]_F(AK)_PF1(PAK)_PFA(AK)_PF2(PAG).pdf

Background: Atypical antipsychotics appear to have the greatest potential to induce weight gain. Antipsychotic-induced weight gain is the one of main cause of non-compliance and discontinuation of treatment, often resulting in the relapse of psychosis. Objective: To compare the weight gain between amisulpride and blonanserin treatment, in persons with psychosis. Materials and Methods: Fifty six subjects with psychosis attending psychiatry department at KR Hospital, Mysore were randomized into two equal groups. After obtaining informed consent, subjects of group I received amisulpride tablets 200 mg BD, and group II received blonanserin tablets 4 mg BD, for eight weeks. Body weight, Body Mass Index (BMI) and Waist Hip Ratio (WHR) were measured at baseline, 4 weeks and 8 weeks. Results: The mean weight gain with amisulpride at 4 weeks was 2.73 kg (5.21%) and at 8 weeks was 4.34 kg (8.28%) from the baseline. The mean weight gain with blonanserin at 4 weeks was 1.77 kg (3.46%) and at 8 weeks was 3.46 kg (6.75%) from the baseline. The mean BMI increase at 8 weeks with amisulpride was 1.66 ± 0.56 and with blonanserin was 1.34 ± 0.77. The mean WHR increase at 8 weeks with amisulpride was 0.036 ± 0.026 and with blonanserin was 0.029 ± 0.020. There was statistically significant increase in weight, BMI and WHR associated with both blonanserin and amisulpride at 8 weeks. But there was no statistically significant difference in those parameters between blonanserin and amisulpride, at eight weeks. Conclusion: Even though there was no significant difference in the weight gain caused by blonanserin, in comparison with amisulpride, both these drugs individually caused significant weight gain at 8 weeks, which is in contrast with the earlier studies, which needs to be further evaluated.