A sensitive bioanalytical method development and validation of cabozantinib in human plasma by LC-ESI-MS/MS

A sensitive bioanalytical method development and validation of cabozantinib in human plasma by LC-ESI-MS/MS

ABSTRACT A simple, sensitive and specific liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for the quantification of cabozantinib (CZ) in human plasma using cabozantinib-d4 (CZD4) as an internal standard (IS). Chromatographic separation was performed on Xbridge C18, 50...

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Bibliographic Details
Main Authors:	Srikanth Inturi, Prameela Rani Avula
Format:	Article
Language:	English
Published:	Universidade de São Paulo 2018-07-01
Series:	Brazilian Journal of Pharmaceutical Sciences
Subjects:	Cabozantinib/human plasma/validation Mass spectrometry Pharmacokinetic/study
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000200622&lng=en&tlng=en

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