Exposure of Induced Pluripotent Stem Cell‐Derived Vascular Endothelial and Smooth Muscle Cells in Coculture to Hemodynamics Induces Primary Vascular Cell‐Like Phenotypes

Exposure of Induced Pluripotent Stem Cell‐Derived Vascular Endothelial and Smooth Muscle Cells in Coculture to Hemodynamics Induces Primary Vascular Cell‐Like Phenotypes

Abstract Human induced pluripotent stem cells (iPSCs) can be differentiated into vascular endothelial (iEC) and smooth muscle (iSMC) cells. However, because iECs and iSMCs are not derived from an intact blood vessel, they represent an immature phenotype. Hemodynamics and heterotypic cell:cell commun...

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Bibliographic Details
Main Authors: Maria S. Collado, Banumathi K. Cole, Robert A. Figler, Mark Lawson, David Manka, Michael B. Simmers, Steve Hoang, Felipe Serrano, Brett R. Blackman, Sanjay Sinha, Brian R. Wamhoff
Format: Article
Language:English
Published: Wiley 2017-08-01
Series:Stem Cells Translational Medicine
Subjects:
Induced pluripotent stem cells
Endothelial cells
Smooth muscle cells
Hemodynamics
Vascular
Online Access:https://doi.org/10.1002/sctm.17-0004

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