[D-Leu<sup>1</sup>]MC-LR Has Lower PP1 Inhibitory Capability and Greater Toxic Potency than MC-LR in Animal and Plant Tissues

[D-Leu<sup>1</sup>]MC-LR Has Lower PP1 Inhibitory Capability and Greater Toxic Potency than MC-LR in Animal and Plant Tissues

Two microcystins, MC-LR and [D-Leu<sup>1</sup>]MC-LR, present in La Plata Basin blooms, are differentiated by substitution of D-Alanine for D-Leucine at position 1. Our objective was to evaluate acute toxicity of [D-Leu<sup>1</sup>]MC-LR and MC-LR in mice (N:NIH Swiss) and be...

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Bibliographic Details
Main Authors: Daniela Sedan, Luciano Malaissi, Cristian Adrián Vaccarini, Ezequiel Ventosi, Martín Laguens, Lorena Rosso, Leda Giannuzzi, Darío Andrinolo
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Toxins
Subjects:
[D-Leu<sup>1</sup>]Microcystin-LR
Microcystin-LR
toxic potency
phosphatase inhibition
<i>Phaseolus vulgaris</i>
mice
Online Access:https://www.mdpi.com/2072-6651/12/10/632

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