An Evaluation of the Delivery of Medicines Using Drones

• Main Authors: Michelle Sing Yee Hii, Patrick Courtney, Paul G. Royall
• Format: Article
• Language: English
• Published: MDPI AG 2019-06-01
• Series: Drones
• Subjects: medicine delivery; insulin; quality of medicines; medicine stability; drone delivery; healthcare logistics; quality by design
• Online Access: https://www.mdpi.com/2504-446X/3/3/52

This study tests the impact of drone transportation on the quality of a medicine. Modelling the critical process parameters of drone flight, the effects of temperature and vibration on insulin were investigated using the pharmacopoeia methods. The medicine, Actrapid, (3.5 mg/mL of insulin), was flown by a quad-rotor drone. Insulin stored between &#8722;20 and 40 &#176;C for 30 mins, and subjected to vibration (0&#8722;40 Hz, 25 &#176;C, 30 mins) passed the pharmacopeia tests. Dynamic light scattering identified the active tetrameric and hexameric forms of insulin post testing. Vibration frequencies during drone flight were between 0.1 and 3.4 Hz. There was no evidence of visible insulin aggregates following the drone transportation. The differences in UV absorbance readings between flown Actrapid and controls were insignificant (<i>p</i> = 0.89). No adverse impact of drone transport on insulin was observed. This study provides supporting evidence that drone transportation of medicinal products containing insulin is feasible. The authors recommend that when considering the drone delivery of medicines five tests need to be applied. These tests must determine the safe flight time and range, the quality of the medicine post flight, the onboard conditions experienced by the medicine, the security of the drone supply chain and the effect of drone failure on both the medicine and the environment.