Autologous mitochondrial microinjection; a strategy to improve the oocyte quality and subsequent reproductive outcome during aging

Autologous mitochondrial microinjection; a strategy to improve the oocyte quality and subsequent reproductive outcome during aging

Abstract Along with the decline in oocyte quality, numerous defects such as mitochondrial insufficiency and the increase of mutation and deletion have been reported in oocyte mitochondrial DNA (mtDNA) following aging. Any impairments in oocyte mitochondrial function have negative effects on the repr...

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Bibliographic Details
Main Authors: Halimeh Mobarak, Mohammad Heidarpour, Pei-Shiue Jason Tsai, Aysa Rezabakhsh, Reza Rahbarghazi, Mohammad Nouri, Mahdi Mahdipour
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Cell & Bioscience
Subjects:
Oocyte quality
Mitochondrial transfer
Ageing
Reproduction
Online Access:https://doi.org/10.1186/s13578-019-0360-5

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