PSMC5 Promotes Proliferation and Metastasis of Colorectal Cancer by Activating Epithelial–Mesenchymal Transition Signaling and Modulating Immune Infiltrating Cells

PSMC5 Promotes Proliferation and Metastasis of Colorectal Cancer by Activating Epithelial–Mesenchymal Transition Signaling and Modulating Immune Infiltrating Cells

We designed the present study to access the roles and mechanisms of PSMC5 in colorectal cancer (CRC). Transcriptomic and clinical data from public datasets and our center were retrospectively analyzed. Functional assays were performed to investigate the effects of PSMC5 on CRC cells. The results sho...

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Bibliographic Details
Main Authors: Zirui He, Xiao Yang, Ling Huang, Leqi Zhou, Sen Zhang, Jing Sun, Minhua Zheng, Junjun Ma, Bo Feng, Lu Zang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
colorectal cancer
metastasis
tumor infiltrated immune cells
PSMC5
m6A
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.657917/full

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