Drug-tunable multidimensional synthetic gene control using inducible degron-tagged dCas9 effectors

Drug-tunable multidimensional synthetic gene control using inducible degron-tagged dCas9 effectors

Deactivated Cas9 fused to transactivation domains can be used to control gene expression, however its presence can prevent rapid switching between different regulatory states. Here the authors generate conditionally degradable dCas9 and Cpf1 proteins for multidimensional control of functional activi...

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Bibliographic Details
Main Authors: Dirk A. Kleinjan, Caroline Wardrope, Si Nga Sou, Susan J. Rosser
Format: Article
Language:English
Published: Nature Publishing Group 2017-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01222-y
Description
Summary:Deactivated Cas9 fused to transactivation domains can be used to control gene expression, however its presence can prevent rapid switching between different regulatory states. Here the authors generate conditionally degradable dCas9 and Cpf1 proteins for multidimensional control of functional activity.
ISSN:2041-1723

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