Ablation of Mrds1/Ofcc1 induces hyper-γ-glutamyl transpeptidasemia without abnormal head development and schizophrenia-relevant behaviors in mice.

Ablation of Mrds1/Ofcc1 induces hyper-γ-glutamyl transpeptidasemia without abnormal head development and schizophrenia-relevant behaviors in mice.

Mutations in the Opo gene result in eye malformation in medaka fish. The human ortholog of this gene, MRDS1/OFCC1, is a potentially causal gene for orofacial cleft, as well as a susceptibility gene for schizophrenia, a devastating mental illness. Based on this evidence, we hypothesized that this gen...

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Main Authors: Tetsuo Ohnishi, Kazuo Yamada, Akiko Watanabe, Hisako Ohba, Toru Sakaguchi, Yota Honma, Yoshimi Iwayama, Tomoko Toyota, Motoko Maekawa, Kazutada Watanabe, Sevilla D Detera-Wadleigh, Shigeharu Wakana, Takeo Yoshikawa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3248446?pdf=render

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