Flaccidoxide-13-Acetate Extracted from the Soft Coral Cladiella kashmani Reduces Human Bladder Cancer Cell Migration and Invasion through Reducing Activation of the FAK/PI3K/AKT/mTOR Signaling Pathway

Flaccidoxide-13-Acetate Extracted from the Soft Coral Cladiella kashmani Reduces Human Bladder Cancer Cell Migration and Invasion through Reducing Activation of the FAK/PI3K/AKT/mTOR Signaling Pathway

Metastasis of cancer is the cause of the majority of cancer deaths. Active compound flaccidoxide-13-acetate, isolated from the soft coral Cladiella kashmani, has been found to exhibit anti-tumor activity. In this study, Boyden chamber analysis, Western blotting and gelatin zymography assays indicate...

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Bibliographic Details
Main Authors: Choo-Aun Neoh, Wen-Tung Wu, Guo-Fong Dai, Jui-Hsin Su, Chih-I Liu, Tzu-Rong Su, Yu-Jen Wu
Format: Article
Language:English
Published: MDPI AG 2017-12-01
Series:Molecules
Subjects:
flaccidoxide-13-acetate
bladder cancer cells
migration
invasion
matrix metalloproteinase
Online Access:https://www.mdpi.com/1420-3049/23/1/58

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