The SUMOylated METTL8 Induces R-loop and Tumorigenesis via m3C

The SUMOylated METTL8 Induces R-loop and Tumorigenesis via m3C

Summary: R-loops, three-stranded DNA-DNA:RNA hybrid structures, are best known for their deleterious effects on genome stability. The regulatory factors of this fundamental genetic structure remain unclear. Here, we reveal an epigenetic factor that controls R-loop stability. METTL8, a member of the...

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Bibliographic Details
Main Authors: Li-Hong Zhang, Xue-Yun Zhang, Tao Hu, Xin-Yun Chen, Jing-Jia Li, Manfred Raida, Ning Sun, Yan Luo, Xiang Gao
Format: Article
Language:English
Published: Elsevier 2020-03-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220301528

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