Epithelial/mesenchymal heterogeneity of high‐grade serous ovarian carcinoma samples correlates with miRNA let‐7 levels and predicts tumor growth and metastasis

Epithelial/mesenchymal heterogeneity of high‐grade serous ovarian carcinoma samples correlates with miRNA let‐7 levels and predicts tumor growth and metastasis

Patient‐derived samples present an advantage over current cell line models of high‐grade serous ovarian cancer (HGSOC) that are not always reliable and phenotypically faithful models of in vivo HGSOC. To improve upon cell line models of HGSOC, we set out to characterize a panel of patient‐derived ce...

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Bibliographic Details
Main Authors: Evgeny Chirshev, Nozomi Hojo, Antonella Bertucci, Linda Sanderman, Anthony Nguyen, Hanmin Wang, Tise Suzuki, Emmanuel Brito, Shannalee R. Martinez, Christine Castañón, Saied Mirshahidi, Marcelo E. Vazquez, Pamela Wat, Kerby C. Oberg, Yevgeniya J. Ioffe, Juli J. Unternaehrer
Format: Article
Language:English
Published: Wiley 2020-11-01
Series:Molecular Oncology
Subjects:
epithelial/mesenchymal transition
high‐grade serous ovarian cancer
microRNA
orthotopic patient‐derived xenografts
stem cells
transcriptional regulation
Online Access:https://doi.org/10.1002/1878-0261.12762

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