Association of Irisin Serum Concentration and Muscle Strength in Normal-Weight and Overweight Young Women

• Main Authors: Ilse Yessabel Martínez Muñoz, Eneida del Socorro Camarillo Romero, Trinidad Correa Padilla, Jonnathan Guadalupe Santillán Benítez, María del Socorro Camarillo Romero, Laura Patricia Montenegro Morales, Gabriel Gerardo Huitrón Bravo, José de Jesús Garduño García
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2019-09-01
• Series: Frontiers in Endocrinology
• Subjects: irisin; health-related to fitness; body composition; muscular strength; fat mass; hand grip strength
• Online Access: https://www.frontiersin.org/article/10.3389/fendo.2019.00621/full

Background: Irisin is a muscle-contraction-induced myokine. In previous studies, it has been related to exercise type, fitness and physical activity; however, evidence is not consistent. Thus, the aim of this study was to research the association between health-related fitness and irisin in young women.Methods: The study was designed as a prospective cross-sectional one. Young, healthy, nonsmoking women were enlisted. The sample comprised 40 overweight (OW) and 40 normal-weight (NW) individuals. The average age was 18.63 ± 0.63 and 18.78 ± 0.73 years, respectively. Components of health-related fitness, metabolic parameters, serum irisin and body composition were analyzed.Results: Statistically significant differences were found in physical tests between NW and OW groups for one-leg standing, hand grip strength, vertical jump, modified push-up, fitness index and maximal oxygen uptake (VO2MAX). There were no differences in concentrations of serum irisin between the groups. We found a positive correlation between irisin and hand grip strength (r = 0.374, p = 0.023). In a multivariate analysis adjusted by body fat, a significant association between irisin and hand grip strength was observed in OW group (β = 0.380, p = 0.026); as well, a positive association between irisin and one-leg standing test in NW group (β = 0.311, p = 0.044) was found.Conclusions: According to our findings, hand grip strength could be linked to irisin concentration in overweight young women.