Effects of Bifidobacterial Supplementation to Pregnant Women and Infants in the Prevention of Allergy Development in Infants and on Fecal Microbiota

Background: Probiotic administration may be a useful method for preventing allergies in infants; however, there have been controversial results about the efficacy. We investigated the effects of bifidobacterial supplementation on the risk of developing allergic diseases in the Japanese population. M...

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Main Authors: Tadao Enomoto, Masanori Sowa, Keiji Nishimori, Shinichiro Shimazu, Akira Yoshida, Kazuko Yamada, Fukumi Furukawa, Takemasa Nakagawa, Naotake Yanagisawa, Noriyuki Iwabuchi, Toshitaka Odamaki, Fumiaki Abe, Jiro Nakayama, Jin-zhong Xiao
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Allergology International
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1323893015300708
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spelling doaj-1387aa3ea7c94c5b8c6eddc8faacaea82020-11-24T21:49:59ZengElsevierAllergology International1323-89302014-01-0163457558510.2332/allergolint.13-OA-0683Effects of Bifidobacterial Supplementation to Pregnant Women and Infants in the Prevention of Allergy Development in Infants and on Fecal MicrobiotaTadao Enomoto0Masanori Sowa1Keiji Nishimori2Shinichiro Shimazu3Akira Yoshida4Kazuko Yamada5Fukumi Furukawa6Takemasa Nakagawa7Naotake Yanagisawa8Noriyuki Iwabuchi9Toshitaka Odamaki10Fumiaki Abe11Jiro Nakayama12Jin-zhong Xiao13NPO (Nonprofit Organization) Japan Health Promotion Supporting NetworkDepartment of Obstetrics and Gynecology, Hidaka General HospitalDepartment of Obstetrics and Gynecology, Hidaka General HospitalDepartment of Pediatrics, Kitade HospitalDepartment of Pediatrics, Japanese Red Cross Society Wakayama Medical CenterSchool of Health and Nursing ScienceDepartent of Dermatology, Wakayama Medical UniversityDepartment of Internal Medicine, Kawazoe Clinic, WakayamaNutrition Scince InstituteFood Science & Technology Institute, Morinaga Milk Industry Co., Ltd., Kanagawa, Fukuoka, Japan.Food Science & Technology Institute, Morinaga Milk Industry Co., Ltd., Kanagawa, Fukuoka, Japan.Food Science & Technology Institute, Morinaga Milk Industry Co., Ltd., Kanagawa, Fukuoka, Japan.Department of Bioscience and Biotechnology, Graduate School, Kyushu University, Fukuoka, Japan.Food Science & Technology Institute, Morinaga Milk Industry Co., Ltd., Kanagawa, Fukuoka, Japan.Background: Probiotic administration may be a useful method for preventing allergies in infants; however, there have been controversial results about the efficacy. We investigated the effects of bifidobacterial supplementation on the risk of developing allergic diseases in the Japanese population. Methods: In an open trial, we gave Bifidobacterium breve M-16V and Bifidobacterium longum BB536 prenatally to 130 mothers beginning 1 month prior to delivery and postnatally to their infants for 6 months. Another 36 mother-infant pairs served as controls and did not receive the bifidobacterial supplementation. Development of allergic symptoms in the infants was assessed at 4, 10 and 18 months of age. Fecal samples were collected from the mothers and infants. Results: The risk of developing eczema_atopic dermatitis (AD) during the first 18 months of life was significantly reduced in infants in the probiotic group (OR: 0.231 [95% CI: 0.084-0.628] and 0.304 [0.105-0.892] at 10 and 18 months of age, respectively). Pyrosequencing analyses indicated an altered composition of the fecal microbiota at 4 months for infants who developed eczema_AD at 4 and 10 months of age. The proportion of Proteobacteria was significantly lower (P = 0.007) in mothers at the time of delivery who received the supplementation when compared with the control group and was positively correlated (r = 0.283, P = 0.024) with that of infants at 4 months of age. No adverse effects were related to the use of probiotics. Conclusions: These data suggest that the prenatal and postnatal supplementation of bifidobacteria is effective in primary preventing allergic diseases. Some limited changes in the composition of fecal microbiota by the bifidobacterial supplementation were observed.http://www.sciencedirect.com/science/article/pii/S1323893015300708allergyBifidobacteriumeczemapreventionprobiotics
collection DOAJ
language English
format Article
sources DOAJ
author Tadao Enomoto
Masanori Sowa
Keiji Nishimori
Shinichiro Shimazu
Akira Yoshida
Kazuko Yamada
Fukumi Furukawa
Takemasa Nakagawa
Naotake Yanagisawa
Noriyuki Iwabuchi
Toshitaka Odamaki
Fumiaki Abe
Jiro Nakayama
Jin-zhong Xiao
spellingShingle Tadao Enomoto
Masanori Sowa
Keiji Nishimori
Shinichiro Shimazu
Akira Yoshida
Kazuko Yamada
Fukumi Furukawa
Takemasa Nakagawa
Naotake Yanagisawa
Noriyuki Iwabuchi
Toshitaka Odamaki
Fumiaki Abe
Jiro Nakayama
Jin-zhong Xiao
Effects of Bifidobacterial Supplementation to Pregnant Women and Infants in the Prevention of Allergy Development in Infants and on Fecal Microbiota
Allergology International
allergy
Bifidobacterium
eczema
prevention
probiotics
author_facet Tadao Enomoto
Masanori Sowa
Keiji Nishimori
Shinichiro Shimazu
Akira Yoshida
Kazuko Yamada
Fukumi Furukawa
Takemasa Nakagawa
Naotake Yanagisawa
Noriyuki Iwabuchi
Toshitaka Odamaki
Fumiaki Abe
Jiro Nakayama
Jin-zhong Xiao
author_sort Tadao Enomoto
title Effects of Bifidobacterial Supplementation to Pregnant Women and Infants in the Prevention of Allergy Development in Infants and on Fecal Microbiota
title_short Effects of Bifidobacterial Supplementation to Pregnant Women and Infants in the Prevention of Allergy Development in Infants and on Fecal Microbiota
title_full Effects of Bifidobacterial Supplementation to Pregnant Women and Infants in the Prevention of Allergy Development in Infants and on Fecal Microbiota
title_fullStr Effects of Bifidobacterial Supplementation to Pregnant Women and Infants in the Prevention of Allergy Development in Infants and on Fecal Microbiota
title_full_unstemmed Effects of Bifidobacterial Supplementation to Pregnant Women and Infants in the Prevention of Allergy Development in Infants and on Fecal Microbiota
title_sort effects of bifidobacterial supplementation to pregnant women and infants in the prevention of allergy development in infants and on fecal microbiota
publisher Elsevier
series Allergology International
issn 1323-8930
publishDate 2014-01-01
description Background: Probiotic administration may be a useful method for preventing allergies in infants; however, there have been controversial results about the efficacy. We investigated the effects of bifidobacterial supplementation on the risk of developing allergic diseases in the Japanese population. Methods: In an open trial, we gave Bifidobacterium breve M-16V and Bifidobacterium longum BB536 prenatally to 130 mothers beginning 1 month prior to delivery and postnatally to their infants for 6 months. Another 36 mother-infant pairs served as controls and did not receive the bifidobacterial supplementation. Development of allergic symptoms in the infants was assessed at 4, 10 and 18 months of age. Fecal samples were collected from the mothers and infants. Results: The risk of developing eczema_atopic dermatitis (AD) during the first 18 months of life was significantly reduced in infants in the probiotic group (OR: 0.231 [95% CI: 0.084-0.628] and 0.304 [0.105-0.892] at 10 and 18 months of age, respectively). Pyrosequencing analyses indicated an altered composition of the fecal microbiota at 4 months for infants who developed eczema_AD at 4 and 10 months of age. The proportion of Proteobacteria was significantly lower (P = 0.007) in mothers at the time of delivery who received the supplementation when compared with the control group and was positively correlated (r = 0.283, P = 0.024) with that of infants at 4 months of age. No adverse effects were related to the use of probiotics. Conclusions: These data suggest that the prenatal and postnatal supplementation of bifidobacteria is effective in primary preventing allergic diseases. Some limited changes in the composition of fecal microbiota by the bifidobacterial supplementation were observed.
topic allergy
Bifidobacterium
eczema
prevention
probiotics
url http://www.sciencedirect.com/science/article/pii/S1323893015300708
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