Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether

Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether

The unfolded protein response (UPR) detects and restores deficits in the endoplasmic reticulum (ER) protein folding capacity. Ceapins specifically inhibit the UPR sensor ATF6α, an ER-tethered transcription factor, by retaining it at the ER through an unknown mechanism. Our genome-wide CRISPR interfe...

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Bibliographic Details
Main Authors: Sandra Elizabeth Torres, Ciara M Gallagher, Lars Plate, Meghna Gupta, Christina R Liem, Xiaoyan Guo, Ruilin Tian, Robert M Stroud, Martin Kampmann, Jonathan S Weissman, Peter Walter
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-05-01
Series:eLife
Subjects:
unfolded protein response
proteostasis
small molecule inhibition
Online Access:https://elifesciences.org/articles/46595

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