Gastric Corpus Mucosal Hyperplasia and Neuroendocrine Cell Hyperplasia, but not Spasmolytic Polypeptide-Expressing Metaplasia, Is Prevented by a Gastrin Receptor Antagonist in H<sup>+</sup>/K<sup>+</sup>ATPase Beta Subunit Knockout Mice

Gastric Corpus Mucosal Hyperplasia and Neuroendocrine Cell Hyperplasia, but not Spasmolytic Polypeptide-Expressing Metaplasia, Is Prevented by a Gastrin Receptor Antagonist in H<sup>+</sup>/K<sup>+</sup>ATPase Beta Subunit Knockout Mice

Proton pump inhibitor use is associated with an increased risk of gastric cancer, which may be mediated by hypergastrinemia. Spasmolytic polypeptide-expression metaplasia (SPEM) has been proposed as a precursor of gastric cancer. We have examined the effects of the gastrin receptor antagonist netaze...

Full description

Bibliographic Details
Main Authors: Kristin Matre Aasarød, Helge Lyder Waldum, Astrid Kamilla Stunes, Arne Kristian Sandvik, Arnar Flatberg, Patricia Mjønes, Unni Syversen, Ingunn Bakke, Reidar Fossmark
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:International Journal of Molecular Sciences
Subjects:
gastrin
netazepide
spem
acid inhibition
neuroendocrine cells
Online Access:https://www.mdpi.com/1422-0067/21/3/927

Internet

https://www.mdpi.com/1422-0067/21/3/927

Similar Items