The SARS-unique domain (SUD) of SARS coronavirus contains two macrodomains that bind G-quadruplexes.

The SARS-unique domain (SUD) of SARS coronavirus contains two macrodomains that bind G-quadruplexes.

Since the outbreak of severe acute respiratory syndrome (SARS) in 2003, the three-dimensional structures of several of the replicase/transcriptase components of SARS coronavirus (SARS-CoV), the non-structural proteins (Nsps), have been determined. However, within the large Nsp3 (1922 amino-acid resi...

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Bibliographic Details
Main Authors: Jinzhi Tan, Clemens Vonrhein, Oliver S Smart, Gerard Bricogne, Michela Bollati, Yuri Kusov, Guido Hansen, Jeroen R Mesters, Christian L Schmidt, Rolf Hilgenfeld
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-05-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2674928?pdf=render

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