Synthesis and Cytotoxic Evaluation of 3-Methylidenechroman-4-ones

Synthesis and Cytotoxic Evaluation of 3-Methylidenechroman-4-ones

In the search for new anticancer agents, a library of variously substituted 3-methylidenechroman-4-ones was synthesized using Horner–Wadsworth–Emmons methodology. Acylation of diethyl methylphosphonate with selected ethyl salicylates furnished 3-diethoxyphosphorylchromen-4-ones w...

Full description

Bibliographic Details
Main Authors: Jacek Kędzia, Tomasz Bartosik, Joanna Drogosz, Anna Janecka, Urszula Krajewska, Tomasz Janecki
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Molecules
Subjects:
3-methylidenechroman-4-ones
Michael addition
Horner–Wadsworth–Emmons olefination
cancer cell lines
apoptosis
Online Access:https://www.mdpi.com/1420-3049/24/10/1868

Internet

https://www.mdpi.com/1420-3049/24/10/1868

Similar Items