Enhanced Bruton’s tyrosine kinase in B-cells and autoreactive IgA in patients with idiopathic pulmonary fibrosis

Enhanced Bruton’s tyrosine kinase in B-cells and autoreactive IgA in patients with idiopathic pulmonary fibrosis

Abstract Rationale Idiopathic Pulmonary Fibrosis (IPF) is thought to be triggered by repeated alveolar epithelial cell injury. Current evidence suggests that aberrant immune activation may contribute. However, the role of B-cell activation remains unclear. We determined the phenotype and activation...

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Bibliographic Details
Main Authors: Peter Heukels, Jennifer A. C. van Hulst, Menno van Nimwegen, Carian E. Boorsma, Barbro N. Melgert, Jan H. von der Thusen, Bernt van den Blink, Rogier A. S. Hoek, Jelle R. Miedema, Stefan F. H. Neys, Odilia B. J. Corneth, Rudi W. Hendriks, Marlies S. Wijsenbeek, Mirjam Kool
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Respiratory Research
Subjects:
Idiopathic pulmonary fibrosis
B-cells
Auto-reactive IgA
Bruton’s tyrosine kinase
Bleomycin
Online Access:http://link.springer.com/article/10.1186/s12931-019-1195-7

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http://link.springer.com/article/10.1186/s12931-019-1195-7

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