The culture microenvironment of juvenile idiopathic arthritis synovial fibroblasts is favorable for endochondral bone formation through BMP4 and repressed by chondrocytes

The culture microenvironment of juvenile idiopathic arthritis synovial fibroblasts is favorable for endochondral bone formation through BMP4 and repressed by chondrocytes

Abstract Background We examined influences of conditioned media from chondrocytes (Ch) on juvenile idiopathic arthritis synovial fibroblasts (JFLS) and potential for JFLS to undergo endochondral bone formation (EBF). Methods Primary cells from three control fibroblast-like synoviocytes (CFLS) and th...

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Bibliographic Details
Main Authors: Megan M. Simonds, Amanda R. Schlefman, Suzanne M. McCahan, Kathleen E. Sullivan, Carlos D. Rose, Anne Marie C. Brescia
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Pediatric Rheumatology Online Journal
Subjects:
Fibroblast
Synoviocyte
Chondrocyte
TGFβ
BMP4
BMP antagonists
Online Access:https://doi.org/10.1186/s12969-021-00556-8

Internet

https://doi.org/10.1186/s12969-021-00556-8

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