Predicting hepatic failure with a new diagnostic technique by preoperative liver scintigraphy and computed tomography: a pilot study in 123 patients undergoing liver resection

• Main Authors: Naokazu Chiba, Motohide Shimazu, Kiminori Takano, Go Oshima, Koichi Tomita, Toru Sano, Masaaki Okihara, Yosuke Ozawa, Kosuke Hikita, Takahiro Gunji, Yuta Abe, Kiyoshi Koizumi, Shigeyuki Kawachi
• Format: Article
• Language: English
• Published: BMC 2017-12-01
• Series: Patient Safety in Surgery
• Subjects: Remnant liver LU15; Hepatic failure; 99mTc-labelled galactosyl human serum albumin liver scintigraphy
• Online Access: http://link.springer.com/article/10.1186/s13037-017-0143-z

Abstract Background A novel index, total liver LU15, has been identified as a surrogate marker for liver function. We evaluated the ability of preoperative remnant liver LU15 values to predict postoperative hepatic failure. Methods Preoperative risk factors for postoperative hepatic failure and remnant liver LU15 were evaluated in 123 patients undergoing liver resection for several diseases from September 1st, 2007 to December 1st, 2016. We calculated the remnant liver LU15 value from the total liver LU15 value and the functional remnant liver ratio. Risk factors for postoperative hepatic failure was determined by univariate and multivariate analysis. Results Hepatic failure grade B/C developed postoperatively in six patients of seven patients within Makuuchi criteria / without criteria for remnant liver LU15. Operative time (p = 0.0242) and criteria for remnant liver LU15 (p = 0.0001) were prognostic factors for hepatic failure according to the univariate analysis. And criteria for remnant liver LU15 (p = 0.0009) was only prognostic factor by multivariate analysis. Conclusion Based on the findings form this pilot study, it appears that patients with a remnant liver LU15 value of 13 or less may have a high risk of postoperative hepatic failure.