Genetic predisposition for the development of complications in patients after coronary artery stenting

• Main Authors: Dana Taizhanova, Akerke Kalimbetova, Aliya Toleuova, Rosa Bodaubay, Olga Visternichan, Aigul Kurmanova
• Format: Article
• Language: English
• Published: National Scientific Medical Research Center 2019-12-01
• Series: Ķazaķstannyṇ Klinikalyķ Medicinasy
• Subjects: coronary heart disease; percutaneous coronary angioplasty; stenting; restenosis; clopidogrel; CYP2C19
• Online Access: https://www.clinmedkaz.org/download/genetic-predisposition-for-the-development-of-complications-in-patients-after-coronary-artery-9070.pdf

In the review the authors analyzed the literature data on the state of knowledge of the problems of genetic polymorphisms CYP2C19 gene response to clopidogrel in patients with acute coronary syndrome. Despite on the technological advances and the widespread use of coronary stenting, restenosis at the site of angioplasty remains the main factor limiting its long-term effectiveness. We made the literature review of the state of the study of the genetic polymorphism of the CYP2C19 gene for a response to clopidogrel in patients with acute coronary syndrome and percutaneous coronary intervention. To achieve this goal, a systematic search and subsequent analysis of publications and online resources were carried out. All publications are indexed in the PubMed, Medline, e-Library, CoogleScholar.