Expression of cyp1a protein in the freshwater clam Corbicula fluminea (Müller)

• Main Authors: Vranković Jelena, Labus-Blagojević Svetlana, Paunović M.
• Format: Article
• Language: English
• Published: University of Belgrade, University of Novi Sad 2011-01-01
• Series: Archives of Biological Sciences
• Subjects: CYP1A; PCBs; Corbicula fluminea
• Online Access: http://www.doiserbia.nb.rs/img/doi/0354-4664/2011/0354-46641101037V.pdf

We investigated the expression of CYP1A in the foot, gill and visceral mass of the freshwater clam Corbicula fluminea in relation to polychlorinated biphenyls (PCBs) exposure. Different PCBs congeners were found in the foot and visceral mass, while the expression of CYP1A was observed only in the visceral mass. However the level of CYP1A expression in the visceral mass was not related to the level of PCBs present in the tissue. Our results indicate a higher rate of biotransformation and lower threshold of CYP1A induction in the visceral mass compared with other tissues.