A Minimum Epitope Overlap between Infections Strongly Narrows the Emerging T Cell Repertoire

A Minimum Epitope Overlap between Infections Strongly Narrows the Emerging T Cell Repertoire

Many infections are caused by pathogens that are similar, but not identical, to previously encountered viruses, bacteria, or vaccines. In such re-infections, pathogens introduce known antigens, which are recognized by memory T cells and new antigens that activate naive T cells. How preexisting memor...

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Bibliographic Details
Main Authors: Susanne G. Oberle, Layane Hanna-El-Daher, Vijaykumar Chennupati, Sarah Enouz, Stefanie Scherer, Martin Prlic, Dietmar Zehn
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Cell Reports
Subjects:
T cell activation threshold
cytotoxic T cells
secondary immune responses
strength of TCR stimulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716313286

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http://www.sciencedirect.com/science/article/pii/S2211124716313286

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