Alterations in mGluR5 expression and signaling in Lewy body disease and in transgenic models of alpha-synucleinopathy--implications for excitotoxicity.

Alterations in mGluR5 expression and signaling in Lewy body disease and in transgenic models of alpha-synucleinopathy--implications for excitotoxicity.

Dementia with Lewy bodies (DLB) and Parkinson's Disease (PD) are neurodegenerative disorders of the aging population characterized by the abnormal accumulation of alpha-synuclein (alpha-syn). Previous studies have suggested that excitotoxicity may contribute to neurodegeneration in these disord...

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Bibliographic Details
Main Authors: Diana L Price, Edward Rockenstein, Kiren Ubhi, Van Phung, Natalie MacLean-Lewis, David Askay, Anna Cartier, Brian Spencer, Christina Patrick, Paula Desplats, Mark H Ellisman, Eliezer Masliah
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-11-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2982819?pdf=render

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