Lymphoepithelioma-like carcinoma of ureter—A rare case report and review of the literature

• Main Authors: Sheng-Chen Wen, Jung-Tsung Shen, Mei-Yu Jang, Kun-Bow Tsai, Shu-Fang Chang, Li-Jiun Tsai, Wen-Jeng Wu
• Format: Article
• Language: English
• Published: Wiley 2012-09-01
• Series: Kaohsiung Journal of Medical Sciences
• Subjects: Epstein–Barr virus; Lymphoepithelioma-like carcinoma; Urothelial; Ureter
• Online Access: http://www.sciencedirect.com/science/article/pii/S1607551X12001040

Lymphoepithelioma-like carcinoma (LELC) is best known to occur in the nasopharynx. When LELC occurs in the urinary tract, this extremely rare neoplasm most commonly affects the bladder but has also been reported in the renal pelvis, ureter, prostate [1], and urethra [2]. We present a case of LELC arising in the right proximal ureter of a 64-year-old male patient with hydronephrosis and nausea. Computed tomography demonstrated right ureter tumor. On biopsy, the patient was diagnosed with infiltrating urothelial carcinoma. An operation consisting of right nephroureterectomy and bladder cuff removal was carried out. The pathologic examination showed pure subtype of LELC, pT3N0. Unlike lymphoepithelioma in the nasopharynx, immunohistochemical analysis of this urinary LELC was negative for the Epstein–Barr virus. No disease progression was noted at 6 months’ follow-up. Only eight previous cases of LELC involving the ureter have been reported, and a review of the available literature and a summary of ureter cases are presented here. This is the first report of a ureteral LELC case and third urothelial LELC cases [3] in Taiwan.