| Summary: | Inertial measurement units (IMUs) are possible alternatives to motion-capture systems (Mocap) for gait analysis. However, IMU-based system performance must be validated before widespread clinical use. Therefore, this study evaluated the validity of IMUs using statistical parametric mapping (SPM) for gait analysis. Ten healthy males (age, 30.10 ± 3.28 years; height, 175.90 ± 5.17 cm; weight: 82.80 ± 17.15 kg) participated in this study; they were asked to walk normally on a treadmill. Data were collected during walking at the self-selected speeds (preferred speed, 1.34 ± 0.10 m/s) using both Mocap and an IMU. Calibration was performed directly before each gait measurement to minimize the IMU drift error over time. The lower-extremity joint angles of the hip, knee, and ankle were calculated and compared with IMUs and Mocap; the hip-joint angle did not differ significantly between IMUs and Mocap. There were significant differences in the discrete (max, min, and range of motion) and continuous variables (waveform: 0–100%) of the knee and ankle joints between IMUs and Mocap, particularly on the swing phase (<i>p</i> < 0.05). Our results suggest that IMU-based data can be used confidently during the stance phase but needs evaluation regarding the swing phase in gait analysis.
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