Effect of different blood purification methods on adipokines and flammatory factor in patients with diabetic nephropathy

• Main Author: Chun Zhong
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2016-02-01
• Series: Journal of Hainan Medical University
• Subjects: Hemodialysis; Hemodialysis with hemoperfusion; Online hemodiafiltration; Adipokine; Lammatory factor
• Online Access: http://www.jhmuweb.net/PDF/201604/8.pdf

Objective: To investigate the effect of in different type hemopurification techniques on adipokine and flammatory factor in diabetic nephropathy with maintenance hemodialysis (MHD). Methods: A total of 81 diabetic nephropathy patients were randomly divided into on hemodialysis group (HD, n=27), hemodialysis with hemoperfusion group (HD+HP, n=27), online hemodiafiltration group (OL-HDF, n=27). Levels of adiponectin, resistin, interleukin-6 (IL-6), and tumor necrosis factor (TNF-α) were tested and compared before and after treatment. Results: Indicators of HD group have no statistical significance before and after treatment. HD+HP and OL-HDF group adiponectin level increased significantly, resistin, IL-6 and TNF-α level decreased significantly before and after treatment; OL-HDF group resistin, IL-6 and TNF-α level decreased more significantly than HD+HP group after treatment. Conclusion: HD+HP and OL-HDF treatments have reliable curative effect on diabetic nephropathy patients, which can regulate adiponectin, resistin, IL-6 and TNF-α level. Effect of OL-HDF treatment eliminates resistin, IL-6 and TNF-α more markedly than HD+HP treatment.