| Summary: | <p>Abstract</p> <p>Background</p> <p>The sex hormone-binding globulin (<it>SHBG</it>) is a carrier protein that modulates the bio-availability of serum sex steroid hormones, which may be involved in ovarian cancer. We evaluated whether common genetic variation in <it>SHBG </it>and its 3' neighbor <it>ATP1B2</it>, in linkage disequilibrium, is associated with the risk of epithelial ovarian cancer.</p> <p>Methods</p> <p>The study population included 264 women with ovarian carcinoma and 625 controls participating in a population-based case-control study in Poland. Five common single nucleotide polymorphisms (SNPs) in <it>SHGB </it>and five in <it>ATP1B2 </it>were selected to capture most common variation in this region.</p> <p>Results</p> <p>None of the SNPs evaluated was significantly associated with ovarian cancer risk, including the putative functional SNPs <it>SHBG </it>D356N (rs6259) and -67G>A 5'UTR (rs1799941). However, our data were consistent with a decreased ovarian cancer risk associated with the variant alleles for these two SNPs, which have been previously associated with increased circulating levels of SHBG.</p> <p>Conclusion</p> <p>These data do not support a substantial association between common genetic variation in <it>SHBG </it>and ovarian cancer risk.</p>
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