Plasminogen Activator Inhibitor-1 Secretion by Autophagy Contributes to Melanoma Resistance to Chemotherapy through Tumor Microenvironment Modulation

Plasminogen Activator Inhibitor-1 Secretion by Autophagy Contributes to Melanoma Resistance to Chemotherapy through Tumor Microenvironment Modulation

Autophagy plays a crucial role in maintenance of cellular homeostasis via intracellular signaling pathways, lysosomal degradation of selective cargo and mediating protein secretion. Dysregulation of autophagy has been implicated in tumorigenesis, tumor progression, and resistance to therapy. However...

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Bibliographic Details
Main Authors: Hong-Tai Tzeng, Jenq-Lin Yang, Yu-Ju Tseng, Chih-Hung Lee, Wei-Ju Chen, I-Tsu Chyuan
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cancers
Subjects:
autophagy
plasminogen activator inhibitor-1
chemotherapy
melanoma
tumor microenvironment
Online Access:https://www.mdpi.com/2072-6694/13/6/1253

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