Structure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-binding

Structure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-binding

Mutations in FAM20A cause tooth enamel defects known as Amelogenesis Imperfecta (AI) and renal calcification. We previously showed that Fam20A is a secretory pathway pseudokinase and allosterically activates the physiological casein kinase Fam20C to phosphorylate secreted proteins important for biom...

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Bibliographic Details
Main Authors: Jixin Cui, Qinyu Zhu, Hui Zhang, Michael A Cianfrocco, Andres E Leschziner, Jack E Dixon, Junyu Xiao
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-04-01
Series:eLife
Subjects:
pseudokinases
secretory pathway kinases
Amelogenesis Imperfecta
enamel formation
pseudoenzymes
protein kinases
Online Access:https://elifesciences.org/articles/23990

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