Dopamine D1 receptor gene variation modulates opioid dependence risk by affecting transition to addiction.

Dopamine D1 receptor gene variation modulates opioid dependence risk by affecting transition to addiction.

Dopamine D1 receptor (DRD1) modulates opioid reinforcement, reward, and opioid-induced neuroadaptation. We propose that DRD1 polymorphism affects susceptibility to opioid dependence (OD), the efficiency of transition to OD, and opioid-induced pleasure response. We analyzed potential association betw...

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Bibliographic Details
Main Authors: Feng Zhu, Chun-xia Yan, Yi-chong Wen, Jiayin Wang, Jinbo Bi, Ya-ling Zhao, Lai Wei, Cheng-ge Gao, Wei Jia, Sheng-bin Li
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3745389?pdf=render

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