Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6

Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6

Oxidative stress and protein aggregation are biochemical hallmarks of Parkinson’s disease (PD), a frequent sporadic late-onset degenerative disorder particularly of dopaminergic neurons in the substantia nigra, resulting in impaired spontaneous movement. PARK6 is a rare autosomal-recessively inherit...

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Bibliographic Details
Main Authors: Hans-Hermann Hoepken, Suzana Gispert, Blas Morales, Oliver Wingerter, Domenico Del Turco, Alexander Mülsch, Robert L. Nussbaum, Klaus Müller, Stefan Dröse, Ulrich Brandt, Thomas Deller, Brunhilde Wirth, Alexei P. Kudin, Wolfram S. Kunz, Georg Auburger
Format: Article
Language:English
Published: Elsevier 2007-02-01
Series:Neurobiology of Disease
Subjects:
Malondialdehyde
MnSOD
Glutathione
Mitochondria
Oxidative stress
PINK1
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106002580

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http://www.sciencedirect.com/science/article/pii/S0969996106002580

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