Apoptotic signalling targets the post-endocytic sorting machinery of the death receptor Fas/CD95

Fas is a death receptor that regulates apoptosis in many cell types and is downregulated on the cell surface in many cancers. Here, Sharma et al. show that endosome associated trafficking regulator ENTR1 regulates delivery of Fas to lysosomes, thereby controlling its degradation and signalling.

Bibliographic Details
Main Authors:	Shruti Sharma, Antonio Carmona, Agnieszka Skowronek, Fangyan Yu, Mark O. Collins, Sindhu Naik, Claire M. Murzeau, Pei-Li Tseng, Kai S. Erdmann
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-11025-y

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spelling	doaj-132fc68029dd4842a59ec193c7636a332021-05-11T11:34:17ZengNature Publishing GroupNature Communications2041-17232019-07-0110111610.1038/s41467-019-11025-yApoptotic signalling targets the post-endocytic sorting machinery of the death receptor Fas/CD95Shruti Sharma0Antonio Carmona1Agnieszka Skowronek2Fangyan Yu3Mark O. Collins4Sindhu Naik5Claire M. Murzeau6Pei-Li Tseng7Kai S. Erdmann8Department of Biomedical Science & Centre of Membrane Interactions and Dynamics, University of SheffieldDepartment of Biomedical Science & Centre of Membrane Interactions and Dynamics, University of SheffieldDepartment of Biomedical Science & Centre of Membrane Interactions and Dynamics, University of SheffieldDepartment of Biomedical Science & Centre of Membrane Interactions and Dynamics, University of SheffieldDepartment of Biomedical Science & Centre of Membrane Interactions and Dynamics, University of SheffieldDepartment of Biomedical Science & Centre of Membrane Interactions and Dynamics, University of SheffieldDepartment of Biomedical Science & Centre of Membrane Interactions and Dynamics, University of SheffieldDepartment of Biomedical Science & Centre of Membrane Interactions and Dynamics, University of SheffieldDepartment of Biomedical Science & Centre of Membrane Interactions and Dynamics, University of SheffieldFas is a death receptor that regulates apoptosis in many cell types and is downregulated on the cell surface in many cancers. Here, Sharma et al. show that endosome associated trafficking regulator ENTR1 regulates delivery of Fas to lysosomes, thereby controlling its degradation and signalling.https://doi.org/10.1038/s41467-019-11025-y
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Shruti Sharma Antonio Carmona Agnieszka Skowronek Fangyan Yu Mark O. Collins Sindhu Naik Claire M. Murzeau Pei-Li Tseng Kai S. Erdmann
spellingShingle	Shruti Sharma Antonio Carmona Agnieszka Skowronek Fangyan Yu Mark O. Collins Sindhu Naik Claire M. Murzeau Pei-Li Tseng Kai S. Erdmann Apoptotic signalling targets the post-endocytic sorting machinery of the death receptor Fas/CD95 Nature Communications
author_facet	Shruti Sharma Antonio Carmona Agnieszka Skowronek Fangyan Yu Mark O. Collins Sindhu Naik Claire M. Murzeau Pei-Li Tseng Kai S. Erdmann
author_sort	Shruti Sharma
title	Apoptotic signalling targets the post-endocytic sorting machinery of the death receptor Fas/CD95
title_short	Apoptotic signalling targets the post-endocytic sorting machinery of the death receptor Fas/CD95
title_full	Apoptotic signalling targets the post-endocytic sorting machinery of the death receptor Fas/CD95
title_fullStr	Apoptotic signalling targets the post-endocytic sorting machinery of the death receptor Fas/CD95
title_full_unstemmed	Apoptotic signalling targets the post-endocytic sorting machinery of the death receptor Fas/CD95
title_sort	apoptotic signalling targets the post-endocytic sorting machinery of the death receptor fas/cd95
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-07-01
description	Fas is a death receptor that regulates apoptosis in many cell types and is downregulated on the cell surface in many cancers. Here, Sharma et al. show that endosome associated trafficking regulator ENTR1 regulates delivery of Fas to lysosomes, thereby controlling its degradation and signalling.
url	https://doi.org/10.1038/s41467-019-11025-y
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Apoptotic signalling targets the post-endocytic sorting machinery of the death receptor Fas/CD95

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