Novel 2-(Adamantan-1-ylamino)Thiazol-4(5<i>H</i>)-One Derivatives and Their Inhibitory Activity towards 11β-HSD1—Synthesis, Molecular Docking and In Vitro Studies

Novel 2-(Adamantan-1-ylamino)Thiazol-4(5<i>H</i>)-One Derivatives and Their Inhibitory Activity towards 11β-HSD1—Synthesis, Molecular Docking and In Vitro Studies

A common mechanism in which glucocorticoids participate is suggested in the pathogenesis of such metabolic diseases as obesity, metabolic syndrome, or Cushing’s syndrome. The enzyme involved in the control of the availability of cortisol, the active form of the glucocorticoid for the glucocorticoid...

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Bibliographic Details
Main Authors: Renata Studzińska, Daria Kupczyk, Wojciech Płaziński, Szymon Baumgart, Rafał Bilski, Renata Paprocka, Renata Kołodziejska
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
11β-hydroxysteroid dehydrogenase 1
glucocorticoids
metabolic disorders
thiazolone derivatives
molecular docking
Online Access:https://www.mdpi.com/1422-0067/22/16/8609

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