Calcium-sensing receptor-mediated NLRP3 inflammasome response to calciprotein particles drives inflammation in rheumatoid arthritis

Calcium-sensing receptor-mediated NLRP3 inflammasome response to calciprotein particles drives inflammation in rheumatoid arthritis

How extracellular calcium can trigger Nlrp3 inflammasome activation has been somewhat controversial and unclear. Here the authors show calciprotein particles are taken up by myeloid cells via calcium-sensing receptor-dependent macropinocytosis in response to high levels of extracellular Ca2+ and thi...

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Bibliographic Details
Main Authors: Elisabeth Jäger, Supriya Murthy, Caroline Schmidt, Magdalena Hahn, Sarah Strobel, Anna Peters, Claudia Stäubert, Pelin Sungur, Tom Venus, Mandy Geisler, Veselina Radusheva, Stefanie Raps, Kathrin Rothe, Roger Scholz, Sebastian Jung, Sylke Wagner, Matthias Pierer, Olga Seifert, Wenhan Chang, Irina Estrela-Lopis, Nora Raulien, Knut Krohn, Norbert Sträter, Stephanie Hoeppener, Torsten Schöneberg, Manuela Rossol, Ulf Wagner
Format: Article
Language:English
Published: Nature Publishing Group 2020-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-17749-6

Internet

https://doi.org/10.1038/s41467-020-17749-6

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