Analysis of Causes of Hospitalization Among Children with Sickle Cell Disease in a Group of Private Hospitals in Jeddah, Saudi Arabia

• Main Authors: Abd El-Ghany SM, Tabbakh AT, Nur KI, Abdelrahman RY, Etarji SM, Almuzaini BY
• Format: Article
• Language: English
• Published: Dove Medical Press 2021-08-01
• Series: Journal of Blood Medicine
• Subjects: vaso-occlusive crisis; acute chest syndrome; infection; hydroxyurea
• Online Access: https://www.dovepress.com/analysis-of-causes-of-hospitalization-among-children-with-sickle-cell--peer-reviewed-fulltext-article-JBM

Shereen M Abd El-Ghany,1,2 Aisha T Tabbakh,3 Khulud I Nur,3 Rayan Y Abdelrahman,3 Sara M Etarji,3 Bayan Y Almuzaini3 1Department of Pediatrics, Ibn Sina National College for Medical Studies, Jeddah, Kingdom of Saudi Arabia; 2Department of Pediatrics, Hematology and Oncology Unit, Ain Shams University, Cairo, Egypt; 3College of Medicine, Ibn Sina National College for Medical Studies, Jeddah, Kingdom of Saudi ArabiaCorrespondence: Shereen M Abd El-GhanyDepartment of Pediatrics, Ibn Sina National College for Medical Studies, Ghulail District, Al Mahjar St., Jeddah, 22421, Kingdom of Saudi ArabiaTel [phone]Fax [phone]Email [e-mail]: Sickle cell anemia (SCA) is a chronic hematologic condition that requires frequent hospitalization representing a significant economic burden on the health services. The aim of this study was to explore the causes and underlying factors of hospitalization among children with SCA, as well as the factors affecting their length of hospital stay.Patients and Methods: This retrospective study included children and adolescents less than 16 years old who were admitted in a group of private hospitals in Jeddah, Saudi Arabia, during the period from January 2018 to December 2019.Results: A total of 94 patients were included in this study, 59.6% were males, with a mean age 7.29 ± 3.82 years. The majority of the patients (91.5%) had sickle cell disease. The most common cause of hospital admission was vaso-occlusive crises (VOC) (64.9%) followed by infection (24.5%), acute chest syndrome (ACS) (18.1%), and acute hemolytic crisis (12.8%). We found no significant difference between gender and different causes of admissions (p > 0.05). While in relation to age group, limb pain and back pain were found to be significantly more frequent among children ≥ 7 years old (p = 0.03,0.04), while infections were significantly more frequent among children < 7 years old (p = 0.003). We analyzed the length of hospital stay and different factors, and we found that the mean length of hospital stay was significantly higher among children who were admitted with infections (p = 0.01) and ACS (p < 0.001) and among children who are non-compliant on hydroxyurea (p = 0.04).Conclusion: The most common cause of hospitalization among children with SCD in Jeddah, Saudi Arabia, was VOC followed by infection, ACS and acute anemia. The length of hospital stay was more prolonged among children with infection and ACS, as well as children who were non-compliant to hydroxyurea.Keywords: vaso-occlusive crisis, acute chest syndrome, infection, hydroxyurea