Mouse Models for Pendrin-Associated Loss of Cochlear and Vestibular Function

Mouse Models for Pendrin-Associated Loss of Cochlear and Vestibular Function

The human gene SLC26A4 and the mouse ortholog Slc26a4 code for the protein pendrin, which is an anion exchanger expressed in apical membranes of selected epithelia. In the inner ear, pendrin is expressed in the cochlea, the vestibular labyrinth and the endolymphatic sac. Loss-of-function and hypo-fu...

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Bibliographic Details
Main Author: Philine Wangemann
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2013-12-01
Series:Cellular Physiology and Biochemistry
Subjects:
Slc26a4
Enlarged vestibular aqueduct
Hearing
Cochlea
Endolymphatic sac
Genetic disease model
Online Access:http://www.karger.com/Article/FullText/356635

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