Inhibition of FGF2-Mediated Signaling in GIST—Promising Approach for Overcoming Resistance to Imatinib

Inhibition of FGF2-Mediated Signaling in GIST—Promising Approach for Overcoming Resistance to Imatinib

Inhibition of KIT-signaling is a major molecular target for gastrointestinal stromal tumor (GIST) therapy, and imatinib mesylate (IM) is known as the most effective first-line treatment option for patients with advanced, unresectable, and/or metastatic GISTs. We show here for the first time that the...

Full description

Bibliographic Details
Main Authors:	Sergei Boichuk, Aigul Galembikova, Ekaterina Mikheeva, Firuza Bikinieva, Aida Aukhadieva, Pavel Dunaev, Dinar Khalikov, Semen Petrov, Refat Kurtasanov, Elena Valeeva, Igor Kireev, Vera Dugina, Anna Lushnikova, Maria Novikova, Pavel Kopnin
Format:	Article
Language:	English
Published:	MDPI AG 2020-06-01
Series:	Cancers
Subjects:	gastrointestinal stromal tumors (GISTs) imatinib (IM) sunitinib (SU) resistance receptor tyrosine kinase (RTK) c-KIT and FGFR-signaling
Online Access:	https://www.mdpi.com/2072-6694/12/6/1674

Similar Items

Targeting of FGF-Signaling Re-Sensitizes Gastrointestinal Stromal Tumors (GIST) to Imatinib In Vitro and In Vivo
by: Sergei Boichuk, et al.
Published: (2018-10-01)

Inhibition of FGFR2-Signaling Attenuates a Homology-Mediated DNA Repair in GIST and Sensitizes Them to DNA-Topoisomerase II Inhibitors
by: Boichuk Sergei, et al.
Published: (2020-01-01)

A Novel Receptor Tyrosine Kinase Switch Promotes Gastrointestinal Stromal Tumor Drug Resistance
by: Sergei Boichuk, et al.
Published: (2017-12-01)

Inhibition of AKT-Signaling Sensitizes Soft Tissue Sarcomas (STS) and Gastrointestinal Stromal Tumors (GIST) to Doxorubicin via Targeting of Homology-Mediated DNA Repair
by: Sergei Boichuk, et al.
Published: (2020-11-01)

Sunitinib in the treatment of gastrointestinal stromal tumor: patient selection and perspectives
by: Mulet-Margalef N, et al.
Published: (2016-12-01)

The outcome and predictive factors of sunitinib therapy in advanced gastrointestinal stromal tumors (GIST) after imatinib failure - one institution study
by: Rutkowski Piotr, et al.
Published: (2012-03-01)

Treatment of gastrointestinal stromal tumours in paediatric and young adult patients with sunitinib: a multicentre case series
by: Piotr Rutkowski, et al.
Published: (2017-11-01)

Oral administration of sunitinib malate for long-term survival of a patient with multiple lung metastases from renal leiomyosarcoma
by: Li X, et al.
Published: (2016-07-01)

Second line of therapy for gastrointestinal stromal tumors: is there a choice?
by: L. M. Kogonia, et al.
Published: (2019-06-01)

A multicenter, dose-finding, phase 1b study of imatinib in combination with alpelisib as third-line treatment in patients with advanced gastrointestinal stromal tumor
by: Bauer, S., et al.
Published: (2022)

Tratamento adjuvante nos GISTs Adjuvant treatment in GISTs
by: Laercio Gomes Lourenço, et al.
Published: (2011-09-01)

Clinicopathologic features and prognostic grouping of gastrointestinal stromal tumors (GISTs) in Pakistani patients: an institutional perspective
by: Atif Ali Hashmi, et al.
Published: (2018-07-01)

GIST and Ghrelin: To Be or Not to Be?
by: Irene Alexandra Spiridon, et al.
Published: (2021-07-01)

Exploring website gist through rapid serial visual presentation
by: Justin W. Owens, et al.
Published: (2019-11-01)

Gastrointestinal stromal tumors (GISTs) of the colon Tumores del estroma gastrointestinal (GIST) del colon
by: F. Macías-García, et al.
Published: (2010-06-01)

Tumores de la estroma gastrointestinal (GIST): aspectos clínicos Gastrointestinal stromal tumors (GIST): clinical aspects
by: L. I. Fernández Salazar, et al.
Published: (2007-01-01)

Gist gástrico gigante metacrono
by: Javier Chinelli, et al.
Published: (2019-07-01)

Long term survival results for gastric GIST: is laparoscopic surgery for large gastric GIST feasible?
by: Kim Ki-Han, et al.
Published: (2012-10-01)

Individualized Management of Blood Concentration in Patients with Gastrointestinal Stromal Tumors
by: Xu H, et al.
Published: (2021-01-01)

Pharmacometric Models for Biomarkers, Side Effects and Efficacy in Anticancer Drug Therapy
by: Hansson, Emma K.
Published: (2012)

GIST- A Rare Tumor in Paediatric Age Group
by: Kulwant Singh Ded, et al.
Published: (2012-04-01)

Management of liver metastases of gastrointestinal stromal tumors (GIST)
by: Nikolaos Vassos, et al.
Published: (2015-07-01)

Personalized Medicine in Gastrointestinal Stromal Tumor (GIST): Clinical Implications of the Somatic and Germline DNA Analysis
by: Gloria Ravegnini, et al.
Published: (2015-07-01)

CT features, mimics and atypical presentations of gastrointestinal stromal tumor (GIST)
by: Smiti Sripathi, et al.
Published: (2011-07-01)

Duodenal GIST metastasized to skull and orbit managed by surgery – A case report
by: Lai-Fung Li, et al.
Published: (2011-10-01)

cKIT Mutations in GISTs and Other Malignancies in Thailand
by: Thongbliew Prempree, et al.
Published: (2006-03-01)

Tumores del estroma gastrointestinal (GIST): factores pronósticos de supervivencia tras citorreducción R0 Gastrointestinal stromal tumors (GIST): factors predictive of survival after R0-cytoreduction
by: J. M. Sánchez Hidalgo, et al.
Published: (2007-12-01)

Efficacy of a Selective Binder of α<sub>V</sub>β<sub>3</sub> Integrin Linked to the Tyrosine Kinase Inhibitor Sunitinib in Ovarian Carcinoma Preclinical Models
by: Andrea Sartori, et al.
Published: (2019-04-01)

2-APCAs, the Novel Microtubule Targeting Agents Active Against Distinct Cancer Cell Lines
by: Sergei Boichuk, et al.
Published: (2021-01-01)

Presentation of GIST as jejuno-jejunal intussusception
by: Anil Kumar, et al.
Published: (2018-03-01)

Imatinib as adjuvant therapy for high risk GIST: a case report
by: Patrizia Lista, et al.
Published: (2015-10-01)

The mechanisms of sensitization of gastrointestinal stromal tumor cells to DNA topoisomerase II inhibitors
by: P D Dunaev, et al.
Published: (2019-12-01)

Simultaneous development of adenocarcinoma and gastrointestinal stromal tumor (GIST) in the stomach: case report
by: Yamamoto Daigo, et al.
Published: (2012-01-01)

Imatinib dose optimisation following the disease progression in a patient with metastatic GIST
by: Mariangela Parodi, et al.
Published: (2015-10-01)

The Emerging Role of the FGF/FGFR Pathway in Gastrointestinal Stromal Tumor
by: Annalisa Astolfi, et al.
Published: (2020-05-01)

Surgical treatment of giant GIST of the cardiac stomach
by: A. L. Charyshkin, et al.
Published: (2019-09-01)

TIPE2 acts as a biomarker for GIST risk category and suppresses the viability and invasiveness of GIST cells
by: Zequn Li, et al.
Published: (2018-12-01)

Perforated GIST in Jejunum – A Rare Cause of Abdominal Cocoon
by: Usha M, et al.
Published: (2014-03-01)

Caractérisation des voies de signalisation des oncogènes FGFR3 muté et FGFR3-TACC3 dans les carcinomes de vessie
by: Mahé, Mélanie
Published: (2015)

Imatinib-induced liver cirrhosis in a patient with advanced gastrointestinal stroma tumor (GIST)
by: Seidel Christoph, et al.
Published: (2012-05-01)