Antimicrobial activity of some sulfonamide derivatives on clinical isolates of Staphylococus aureus

• Main Authors: Bekdemir Yunus, Özkanca Reşit, Genç Yeliz
• Format: Article
• Language: English
• Published: BMC 2008-08-01
• Series: Annals of Clinical Microbiology and Antimicrobials
• Online Access: http://www.ann-clinmicrob.com/content/7/1/17

<p>Abstract</p> <p>Background</p> <p><it>Staphylococcus aureus </it>is a non-motile, gram positive, non-sporforming, facultative anaerobic microorganism. It is one of the important bacteria as a potential pathogen specifically for nosocomial infections. The sulfonamide derivative medicines are preferred to cure infection caused by <it>S. aureus </it>due to methicillin resistance.</p> <p>Methods</p> <p>Antimicrobial activity of four sulfonamide derivatives have been investigated against 50 clinical isolates of <it>S. aureus </it>and tested by using MIC and disc diffusion methods. 50 clinical isolate which collected from specimens of patients who are given medical treatment in Ondokuz Mayis University Medical School Hospital. A control strain of <it>S. aureus </it>ATCC 29213 was also tested.</p> <p>Results</p> <p>The strongest inhibition was observed in the cases of <b>I </b>[<it>N</it>-(2-hydroxy-4-nitro-phenyl)-4-methyl-benzensulfonamid], and <b>II </b>[<it>N</it>-(2-hydroxy-5-nitro-phenyl)-4-methyl-benzensulfonamid] against <it>S. aureus</it>. Compound <b>I </b>[<it>N</it>-(2-hydroxy-4-nitro-phenyl)-4-methyl-benzensulfonamid] showed higher effect on 21 <it>S. aureus </it>MRSA<it/>isolates than oxacillin antibiotic. Introducing an electron withdrawing on the ring increased the antimicrobial activity remarkably.</p> <p>Conclusion</p> <p>This study may help to suggest an alternative possible leading compound for development of new antimicrobial agents against MRSA and MSSA resistant <it>S. aureus</it>. It was also shown here that that clinical isolates of 50 <it>S. aureus </it>have various resistance patterns against to four sulfonamide derivatives. It may also be emphasized here that in vitro antimicrobial susceptibility testing results for <it>S. aureus </it>need standardization with further studies and it should also have a correlation with in vivo therapeutic response experiments.</p>